WebIn addition, intestinal HIF-2α is a major mechanism by which local intestinal iron absorption from the gut lumen is regulated. HIF-2α is the key transcription factor that promotes intestinal iron absorption by regulating the expression of DcytB, DMT-1, and FPN in the intestine ( 40, 51, 80 – 82) ( Table 1 ). Web5 de dez. de 2024 · Anemia is a common feature and complication of chronic kidney disease (CKD). Erythropoiesis-stimulating agents (ESAs) and recombinant human …
Selective tubular activation of hypoxia-inducible factor-2α …
Web9 de jul. de 2009 · For example, whereas both proteins regulate many common hypoxia-induced target genes such as VEGF, 14 HIF-1α (but not HIF-2α) activates the hypoxic expression of genes encoding glycolytic enzymes such as PGK and ALDA. 14,15 In contrast, HIF-2α uniquely regulates the gene encoding the critical stem cell factor Oct-4 … Web25 de mai. de 2024 · 5003 Background: Patients (pts) with Von Hippel-Lindau disease (VHL) are at risk for several cancers, including clear cell renal cell carcinoma (ccRCC). Inactivation of VHL results in constitutive activation of the HIF-2α transcription factor, which drives tumor growth. MK-6482, a potent, selective, small molecule HIF-2α inhibitor, has … florence nightingale comprehension year 2
Phase 3 Study to Evaluate HIF-2α Inhibitor in RCC
Web低氧诱导因子是一种在体内广泛存在的碱性多肽-螺旋-环-螺旋转录因子,是迄今为止发现的惟一的特异性调节氧稳态的关键介质.近年研究发现,HIF与肾脏血管发育调控、肾髓质氧合作用调节、急、慢性肾功能不全的发生发展有密切的关系. Web方法: 逆转录PCR (reverse transcription-polymerase chain reaction, RT-PCR)和Sanger测序检测不同肿瘤细胞中由HIF1α-SNAPC1形成的转录通读RNA和rt-circ-HS的表达。. 构建不同类型的肾细胞癌 (renal cell carcinoma，RCC)组织芯片共437例，用原位杂交检测rt-circ-HS表达。. 采用小干扰RNA (small ... Web2 de abr. de 2006 · The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease. Over the past decade major advances have been made in our understanding of the molecular machinery that mammalian cells use to sense and to adapt to a low-oxygen environment. A critical mediator of cellular adaptation to hypoxia is hypoxia-inducible … florence nightingale cloze